At Significantly Higher Risk • Cigarette smokers. • The male to female ratio remains 4 to 1. Peak incidence occurs between ages 50 and 60, with less than a 1 percent incidence under the age of 30 and about a 10 percent incidence in people over 70. • Workers exposed to industrial substances such as asbestos, nickel, chromium compounds and chloromethyl ether, especially those who smoke. At Slightly Higher Risk • Patients with previous or pre-existing lung disease. • Former smokers. • People exposed to second-hand smoke over many years. • People exposed to radon.